We found that topical treatment with CGRP promotes tissue repair and limits injury-induced corneal opacity by enhancing epithelial cell proliferation and migration, restoring epithelial basement membrane integrity, suppressing TGF-β1-mediated tissue fibrosis, decreasing neutrophil infiltration and macrophage activation, inhibiting expression of pro-inflammatory mediators, and preserves corneal endothelial cell density and function (Fig.8). This evidence concerns the gene CALCA and Corneal opacity.