MSH6 and cancer: When examining the relationship between ANKRD1 expression and essential MMR signatures (PMS1 homolog 2 (PMS2), MutL homolog 1 (MLH1), MutS homolog 2 (MSH2) and MutS homolog 6 (MSH6), and epithelial cell adhesion molecule (EPCAM)), significant associations were observed in most cancers, except ACC, CHOL, DLBC, KICH, KIRC, OV, SARC, STAD, and UVA (Fig. 10).