The UBE3C-LRP5 (v1) variant is a fusion of inverted exon 23 of UBE3C, with 12 bp of retained intron 5 of LRP5 and exon 6–23 of LRP5. The UBE3C-LRP5 (v2) variant is a fusion of inverted exon 23 of UBE3C and exon 6–23 of LRP5 with a deletion of 188 bases from the start of exon 6 of LRP5. To examine the presence of both LRP5-UBE3C (v1, v2), and UBE3C-LRP5 (v1, v2) fusion variants, we performed RT-PCR analysis on the cDNA from a total of 151 head and neck tumor samples. This evidence concerns the gene LRP5 and head and neck neoplasm.