We asked if NT-8e cells, which endogenously express the UBE3C-LRP5 (v1 and v2) fusion variants, display sensitivity to pyrvinium pamoate and performed MTT assay with the HNSCC cell lines (AW13516, AW8507, and NT-8e). The gene discussed is UBE3C; the disease is head and neck squamous cell carcinoma.