The results showed that CCL5 and IDH2 were not significantly differentially methylated in BRCA, while CCR7, EZR, IL8, and IL2RG were hypermethylated in normal tissues, and FLT3, MAPK10, and MMP9 were hypermethylated in breast tumor tissues (Fig. 12A). The gene discussed is IDH2; the disease is breast neoplasm.