GLS2 and cancer: It will also be interesting to see how post-translational modifications such as lysine succinylation, which occur at specific sites on GAC and have been suggested to both promote enzyme activation by stimulating oligomer (tetramer) formation29 and to enhance ubiquitination and degradation52, affect filament formation, as well as whether the ankyrin repeats are responsible for conferring GLS2 with functional capabilities distinct from those of GAC in different cancers.