The effects of BMS-202 were not obvious at the protein and mRNA levels in glioma cells; therefore, we speculate that the effects of BMS-202 treatment occur predominantly on the glioma cell surface and that changes in glioma cells are derived from alterations in the PD-L1 structure, which is consistent with the findings from previous studies [12, 13]. Here, CD274 is linked to central nervous system cancer.