Seven of the significant colocalizing variants were present at 3 known AMD loci (C2/CFB/SKIV2L, PILRB/PILRA and CNN2) corresponding to 3 genes (Fig. 5c), and 11 of the colocalizing variants proposed 7 new AMD associations (Table 2). The gene discussed is SKIC2; the disease is age-related macular degeneration.