At the CFI locus, SMR detected SNP rs7439493 influencing PLA2G12A expression and AMD risk (SMR P value = 2.6 × 10−8 and HEIDI P value = 0.22) (Supplementary Fig. 6a), as identified in our previous eQTL study32. Here, PLA2G12A is linked to age-related macular degeneration.