MGMT and glioblastoma: We also investigated TMZ induced TLS activity and DNA damage markers in other well-studied GBM cell lines (LN228 MGMT-, D54 MGMT- Supplementary Fig. 7), GBM patient-derived lines (MS21 MGMT-, GBM8 MGMT- Supplementary Fig. 8)49,50, and Mayo clinic GBM patient-derived xenografts (PDXs) (GBM75 MGMT-, GBM123 MGMT+, GBM12 MGMT-, GBM85 MGMT- provided by Dr. Jann Sarkaria, Mayo Clinic) (Supplementary Fig. 9).