RAD18 and glioblastoma: Taken together, we show that RAD18-mediated DNA damage tolerance and mutagenesis are dissociable in TMZ-treated GBM: RAD18 mediates tolerance of TMZ-induced DNA damage (Figs. 1, 2) and facilitates error-free bypass of the most cytotoxic and mutagenic TMZ-induced lesion (O6mG).