During the past four decades, the lipid peroxidation process has been shown to play crucial roles in cell biology and human health, wherein lipid kinases catalyze the production of lipids.27 By comparing the proteomic data of our study and the lipid kinases of KiNativ,28 a Venn diagram reveals four intersected kinases (PIP4K2A, ITPKB, ITPK1, and PRKDC) (Fig. 1c), which may be associated with glioma recurrence. This evidence concerns the gene ITPK1 and central nervous system cancer.