Inositol-1,4,5-triphosphate (IP3) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that phosphorylates IP3, an intracellular secondary messenger that stimulates calcium release and mitochondrial ATP production.16 GNF362, a pharmacological inhibitor of ITPKB with high potency and selectivity, increases intracellular Ca2+ and apoptosis of activated T cells.4,17 Emerging evidence supports that dysregulated ITPKB is associated with resistance to chemotherapy in cancers through the activation of NADPH oxidase (NOX). This evidence concerns the gene ITPKB and cancer.