ITPKB and central nervous system cancer: ITPKB, an essential cellular enzyme, catalyzes the inositol phosphate phosphorylation of the second messenger inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4), regulating intracellular calcium fluxes.17 Data from the Chinese Glioma Genome Atlas database (CGGA, http://www.cgga.org.cn/)29 demonstrated that high ITPKB expression was correlated with a poorer survival probability (Fig. 1h).