Given that a few recent studies suggested that JPH2 interacts with phospholipids in the PM and that JPH2 ablation in human induced pluripotent stem cell–derived cardiomyocytes impaired fatty acid oxidation, we set out to perform a comprehensive lipidomic analysis of two knock-in mouse models of JPH2-induced cardiomyopathies. This evidence concerns the gene JPH2 and cardiomyopathy.