Future studies could involve similar knockdown analysis of other cancer-associated genes and transcription factors, such as oncogenes (KRASG12D, EGFR, and VEGF), proinflammatory transcription factors (NF-kB, AP-1, and STAT3), and cell proliferation transcription factors (c-MYC, E2F, and ETS1), followed by downstream protease activity analysis (43). Here, STAT3 is linked to cancer.