GAK-knockdown in NOD1-overexpressing breast cancer cells (Fig. S17A) significantly inhibited NOD1-induced cell proliferation (Fig. S17B), suppressed BCSC enrichment (Fig. S17C and S17D) and re-sensitized cells to DTX (Fig. S17E), suggesting that GAK-knockdown reversed phenotype induced by NOD1-overexpressing. Here, GAK is linked to breast carcinoma.