However, considering the potential beneficial effects of drugs that inhibit HSP90 activity in these neurodegenerative diseases, the availability of PET imaging ligands targeting HSP90 may allow us to track changes in HSP90 levels in these diseases and they could also be an additional ligand to the arsenal currently used for pathophysiological studies of neurodegenerative diseases in general. The gene discussed is HSP90AA1; the disease is neurodegenerative disease.