Strikingly, we observed that PANo-RPI had a significant positive correlation with immune-related signatures (including antigen processing machinery, immune checkpoints, and effector CD8+T cells), whereas it showed a strong negative correlation with DNA damage and repair pathways (such as nucleotide excision repair, DNA damage response, mismatch repair, DNA replication, and base excision repair) in almost all human cancers (Fig. 6A and Table S4). This evidence concerns the gene CD8A and cancer.