To address whether GSDMD/Caspase-11 in hematopoietic cells takes responsibility for renal fibrosis in hyperuricemic nephropathy, we generated hematopoietic cells-specific Gsdmd-deficient mice and hematopoietic cells-specific Caspase-11-deficient mice by crossing Gsdmd floxed mice (Gsdmdfl/fl mice) and Caspase-11 floxed mice (Caspase-11fl/fl mice) with Vav-Cre-expressing mice on a C57BL/6 background, respectively. The gene discussed is GSDMD; the disease is Nephropathy.