Given the pivotal role of generation and activation of proinflammatory and profibrogenic factors in the progression of renal fibrosis, we probed into the influence of Caspase-11/GSDMD on the generation of the selected factors, including interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNFα), transforming growth factor-beta1 (TGF-β1), and high-mobility group box-1 (HMGB1) in the kidney by ELISA. Here, TNF is linked to renal fibrosis.