GSDMD and renal fibrosis: Compared with WT mice (Vav-Cre), hematopoietic cells-specific Gsdmd-deficient mice (Vav-Cre Gsdmdfl/fl) and hematopoietic cells-specific Caspase-11-deficient mice (Vav-Cre Caspase-11fl/fl) showed a pronounced reduction in renal fibrosis after daily feeding of adenine for 14 days and 28 days (Fig. 6A, B).