To address the question of whether Caspase-11/GSDMD played a vital role in NETs generation in hyperuricemic nephropathy, we accessed the expression of myeloperoxidase (MPO) and histone H3 (H3) in the kidney tissue from Gsdmd−/− mice, Caspase-11−/− mice, and WT control mice. This evidence concerns the gene GSDMD and kidney disorder.