DUX4 and sarcoma: CIC-rearranged sarcomas most commonly harbor fusions involving the DUX4 gene creating a chimeric fusion, CIC::DUX4.  The CIC::DUX4 fusion juxtaposes the DNA-binding domain of the Capicua (CIC) transcriptional repressor with the variable region of the double homeobox 4 (DUX4) transcription factor via a t(4;19)(q35;q13) translocation (Italiano et al. 2012; Rekhi et al. 2023; Satomi et al. 2022).