In addition to its beneficial properties concerning the regulation of glucose and lipid metabolism [12, 13] as well as inflammation [14, 15], inverse associations of circulating CTRP3 with cardio-metabolic risk factors and protective effects in cardiovascular diseases have been reported previously [11, 16], including atherosclerosis and acute coronary syndrome (ACS) [17, 18]. This evidence concerns the gene C1QTNF3 and atherosclerosis.