TBX21 and Autoimmunity: As revealed by evidencing studies, NLRC3 increases many genes related to the activation of Th1/Th17/T cells, such as Ifng, Tnf, Il17f, Il17a, and Tbx21; also, study reveals that Nlrc3 expression in T cells inhibits autoimmunity as well as CD4+ T cell responses specific for virus [15].