We then established APE1 knockdown (APE1_KD) and overexpression (APE1_OE) cell lines on another ovarian cancer cell line A2870 (Supplementary Fig. 2E) and found that APE1 also facilitated SG formation after H2O2 or cisplatin treatment (Supplementary Fig. 2F–M). This evidence concerns the gene APEX1 and ovarian carcinoma.