For example, monocytopenia and mycobacterial infection (MonoMAC) syndrome is typically caused by LOF coding variants within the gene GATA2. However, MonoMAC syndrome can also be caused by small deletions or single-nucleotide variants (SNVs) in a GATA2 intronic enhancer 9.5 kb downstream of the GATA2 promoter. This evidence concerns the gene GATA2 and Decreased total monocyte count.