POMC and glucocorticoid-remediable aldosteronism: For example, glucocorticoid-remediable aldosteronism (GRA) is caused by ‘promoter switching’ between the genes CYP11B1 and CYP11B2, resulting in a chimeric gene wherein the adrenocorticotropic hormone (ACTH)-responsive promoter of the 11-beta-hydroxylase gene (CYP11B1) is fused with the coding region of the aldosterone synthase gene (CYP11B2) (Lifton et al. 1992).