Magi2 polymorphisms may also influence nicotine dependence in smokers [72]; and 6) FK506 binding protein 5 (Fkbp5) which has been linked to DNAm changes in blood as discussed, but also modulates the effects of nicotine on the hypothalamic pituitary adrenal axis in female smokers [73]. Here, MAGI2 is linked to substance dependence.