This might be due to women’s longer life expectancy in comparison to men and the dementia risk factors attributable to sex as it seems to happen with APOE and total tau levels for Alzheimer’s disease.23,24 This information advises on the need to work closely with women by alerting them about the symptoms of the disease and through implementing prevention actions in this group. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.