We conducted mediation analysis to explore the mediating role of inflammatory ormetabolic factors in the association between depression PGIRS and cardiac and lungfunctions, and observed several significant mediating effects (Table S5, see Supplementary Data availableonline at http://bib.oxfordjournals.org/).For instance, in smoking individuals, CRP positively mediated the negative relationshipbetween PGIRS-smoke and FVC (βIndirect = −0.003,βTotal = −0.034). The gene discussed is CRP; the disease is major depressive disorder.