MMP-24 was detected in malignant glioma, breast cancer and ovarian cancer.38,39 Studies have showed that MMP24 mRNA was overexpressed in gastric cancer, which was probably related with tumor metastasis.40 Based on our results, it is presumed that salidroside may inhibit the proliferation and invasion of gastric cancer cells by down-regulating MAP3K6/MMP24 signaling molecules through up-regulating miR-1343-3p. The gene discussed is MAP3K6; the disease is gastric cancer.