As an intestinal nutrient regulator, probiotics have played a protective role in ultrafine particle-induced colitis21 and perfluorobutane sulfonate-induced dysplasia.46 In addition, probiotic-based therapeutic strategies have been reported to help reduce the side effects of chemotherapy and eliminate multiple drug-resistant strains of bacteria in patients with hematologic malignancies.47 As expected, oral probiotics can restore abnormally elevated LCFAs, IL-5, and disturbed hematopoietic function. Here, IL5 is linked to dysplasia.