NFKB1 and Obesity: Recently, it has been suggested that sporoderm-broken spores of Ganoderma lucidum (BSGLP) can inhibit the upregulation of the NF-κB signaling pathway in adipose tissue induced by a high-fat diet (HFD), thus suppressing obesity and hyperlipidemia by modulating inflammation, gut microbiota, and intestinal tract barrier function (Sang et al., 2021).