Recently, it has been suggested that sporoderm-broken spores of Ganoderma lucidum (BSGLP) can inhibit the upregulation of the NF-κB signaling pathway in adipose tissue induced by a high-fat diet (HFD), thus suppressing obesity and hyperlipidemia by modulating inflammation, gut microbiota, and intestinal tract barrier function (Sang et al., 2021). This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.