For example, A recent investigation has suggested that METTL3 enhances the proliferation, formation of colonies, migration, and invasion of GC cells in an m6A-dependent manner via the pre-B-cell leukemia homeobox 1 (PBX1)/GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4) axis (Liu et al., 2022). This evidence concerns the gene PBX1 and gastric cancer.