On the other hand, senescent cells secrete excess growth factors and cytokines (Coppé et al., 2010), including interleukin 8 (IL-6) and IL-6 (collectively referred to as SASP) (Lasry & Ben-Neriah, 2015), thus establishing a microenvironment of immunosuppression, inflammation, and catabolism to promote chemotherapeutic resistance and tumor growth (Coppé et al., 2008). The gene discussed is IL6; the disease is neoplasm.