Among them, cancer-associated fibroblasts often present a senescence-associated secretory phenotype (SASP) under stress conditions such as inflammatory factors, which promotes tumor formation and chemoresistance through the release of cytokine IL-6, which also reveals the relevant mechanism of cellular senescence-associated cancer progression from the level of regulation of the immune microenvironment (Yasuda et al., 2021; Wu et al., 2017). The gene discussed is IL6; the disease is cancer.