Moreover, when all cancer patients were divided into four groups by the quartiles of MRV and Hb levels of male and female patients, the incidence of overall anemia demonstrated an increase trend along with the decrease of MRV and Hb quartiles, respectively (p-trend<0.01), but which was based on MRV quartile showed a more significant decrease (Fig. 2). This evidence concerns the gene GSTM1 and cancer.