ALB and hereditary elliptocytosis: Most of the arms showed a significant reduction in the incidence of development of overt HE compared with albumin and placebo. The order of drugs in terms of incidence of development of overt HE according to P-score is (Lactulose and Rifaximin), (Rifaximin and L-carnitine), (Lactulose and Rifaximin with zinc), Nitazoxanide, Probiotics, Lactulose, L-ornithine L-aspartate, Rifaximin, placebo, and Albumin (Figure 3).