The gene, which encodes the MTHFD1 enzyme, is located on the long arm of chromosome 14 (14q 24). MTHFD1 is a trifunctional enzyme and is a maternal risk for severe placental abruption [19]. MTHFD1 has catalytic activity, which is indirectly involved in purines, and pyrimidine synthesis is mainly required for de novo DNA synthesis for embryonic development [19]. Here, MTHFD1 is linked to placental abruption.