Known CLL prognostic genes (i.e., LPL, ZAP70, and NOTCH1), epigenetic regulators (HDAC9/4 and DNMT3B), B-cell signaling, and numerous TGF-β and NF-κB/TNF pathway genes were differentially methylated between the subgroups [14]. This evidence concerns the gene TGFB1 and B-cell chronic lymphocytic leukemia.