To elucidate the effect of signaling pathways on the expression of genes involved in the metabolic activity of AML cells, we investigated the relationship between the inhibitors of the PI3K/AKT/mTOR pathway and the expression of genes in glycolysis, the pyruvate dehydrogenase (PDH) complex, and the TCA cycle in AML cells. This evidence concerns the gene AKT1 and acute myeloid leukemia.