Differential gene expression analyses revealed alterations in expression of genes (Bcl2, Il3ra that encodes for CD123, Sox4, Igll1, Egfr, Irf4, Cxcr3) that typically dysregulated in BPDCN (Figure 2A).21 The gene discussed is BCL2; the disease is CD4+/CD56+ hematodermic neoplasm.