MBP and myeloid sarcoma: In MS models, early pioneering studies showed that T cell receptor (TCR)-transgenic mice specific for myelin basic protein (MBP), a major neural antigen, succumbed to experimental autoimmune encephalitis (EAE), a mouse model of MS, when such animals were crossed onto a genetic background that precluded a development of TREGS while allowing a development of autoreactive T cells (Lafaille et al., 1994).