SNCA and Parkinson disease: Parkinson’s, analogous to prion disease involves a complex interplay between genetic, environmental, and cellular factors, neuronal dysfunction, and neurodegeneration (Brundin et al., 2016; Meade et al., 2019; Jan et al., 2021).The pathogenesis of Parkinson’s disease is portrayed by the atypical aggregation of a protein called α-synuclein usually exists in a folded state within neurons (Iwatsubo, 2003; Stefanis, 2012; Burre, 2015).