Despite this, α-synuclein misfolds in Parkinson’s disease (PD), changing from its normally soluble form to an insoluble, aggregated form (Sharon et al., 2003; Breydo et al., 2012; Stefanis, 2012; Mehra et al., 2019; Vidovic and Rikalovic, 2022). Here, SNCA is linked to Parkinson disease.