The results of this study showed that diabetes body mass growth rate ≥ 5.54%, TG ≥ 1.40 mmol/ L, NT-proBNP ≥ 5.82 ng/L, SBP-SD ≥ 13.52, SBP-CV ≥ 8.63, DBP-SD ≥8.14, and DBP-CV ≥ 8.82 were risk factors for MACCE in uraemia patients with hypertension. The gene discussed is NPPB; the disease is Hypertension.