PMS and PMDD are factors that contribute to decreased ability to perform daily activities and lead to worsening of relationships.4,5 PMS causes have been variously attributed to estrogen; progesterone's effects on neurotransmitters, such as serotonin, opioids, catecholamines, and γ-amino butyric acid; the phenomenon of cortisol; adrenal dysfunction; vitamin B6 deficiency; increased prolactin levels; and insulin resistance.6,7 However, these are not yet fully understood. Here, PRL is linked to premenstrual tension.