IL1B and Cognitive impairment: We previously reported that neuronal IL1-β activation is associated with post-injury cognitive deficits after a single CHI in adult mice and that IL-1R1 deletion prevented these deficits.6Figure 2 shows the results of western blots for IL-1β in neurons and endothelium (CD31+) isolated by immunopanning at 24 h after sham or CHI.