SPG11 and Anxiety: Here, we established a behavioral test battery that revealed abnormalities in social, hyperactivity-like, anxiety-like, and impulsivity-like behavior of Spg11−/− mice, all being relevant for SPG11 patients (Wijemanne et al., 2015; Faber et al., 2018; Utz et al., 2022; Klebe et al., unpublished data).