We provide evidence that our SPG11 model shows distinct behavioral abnormalities, including abnormal social, impulsivity-like, anxiety-like, and hyperactivity-like behavior, which partially reflects neuropsychological changes seen in patients (Wijemanne et al., 2015; Faber et al., 2018; Utz et al., 2022; Klebe et al., unpublished data). This evidence concerns the gene SPG11 and Anxiety.