The effect of the mutations on the p53 aggregation is well documented in several reports and specified as the plausible reason for the loss of tumour suppressive function of the p53 (Ano Bom et al., 2012; Freed-Pastor and Prives, 2012; Pedrote et al., 2020; Silva et al., 2014; Xu et al., 2011). Here, TP53 is linked to neoplasm.