Mutations in cancer cell metabolism genes are also involved in the production of chromatin-modifying metabolites, including loss-of-function succinate dehydrogenase (SDH) and fumarate hydratase (FH) mutations, as well as IDH mutations, which can lead to the accumulation of 2-hydroxyglutarate and downregulation of tumor suppressor genes and cellular differentiation blockade via DNA and histone hypermethylation 55. This evidence concerns the gene FH and cancer.