FN1 and neoplasm: Cellular components of tumor environment include infiltrating stromal cells (cancer-associated fibroblasts; CAFs), immune cells (tumor-infiltrating lymphocytes: TILs, tumor-infiltrating macrophages: TAMs) and vascular-associate cells (endothelial cells; ECs, pericytes; PCs), and extracellular components include collagens, fibronectin, laminin and secreted growth factors and enzymes like matrix metalloproteinases.