They found that LPA receptor 1 (LPAR1) is notably upregulated in osteosarcoma, such that the pharmacological inhibition of LPAR1 by the orally available LPAR1 antagonist, ONO-7300243, prevented pulmonary metastasis of osteosarcoma in the mouse models, indicating that the LPA-LPAR1 axis is essential for the osteosarcoma invasion and metastasis, and targeting LPAR1 would be a promising therapeutic intervention for advanced osteosarcoma 127. The gene discussed is LPA; the disease is osteosarcoma.