Platelets also enhance the proliferation and motility of tumor and endothelial cells promoting tumor growth, metastasis, and angiogenesis by releasing bioactive molecules 122, including peptide mediators such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), chemokine ligands (CXCL) 4,7 and 12 123,124 as well as lipid mediators such as thromboxane A2 (TxA2), sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) 125,126. Here, VEGFA is linked to neoplasm.