To further confirm the causal relationship between immunophenotypes and breast cancer, we performed reverse MR analyses for the three positive results mentioned above (CD11c+ HLA-DR++ cDC, HLA-DR on plasmacytoid DC, and HLA-DR on DC) and the results did not find any evidence of breast cancer's effect on the evidence of an impact of immunophenotypes risk. Here, ITGAX is linked to breast carcinoma.