Interestingly, higher TKT expression was shown to correlate with prognosis in HCC (overall survival: HR=2.34, 95%CI=1.63 to 3.35, P =1.7e-6; recurrence free survival: HR=1.91, 95%CI=1.34 to 2.71, P=0.00027; PFS: HR=1.59, 95%CI=1.16 to 2.16, P=0.0033; disease specific survival: HR=2.22, 95%CI=1.39 to 3.55, P=0.00061) (Fig 6A-D). This evidence concerns the gene TKT and hepatocellular carcinoma.