Studies have shown that lycorine has a good anti-cancer effect in liver cancer; it inhibits the proliferation and migration of HepG2 cells by inhibiting ROCK1/cofilin-induced actin22, promotes apoptosis and autophagy of HCC cells via the TCRP1/AKT/mTOR pathway9, and induces mitochondria-dependent apoptosis in HCC cells23. Here, CFL1 is linked to liver cancer.