MAP2K2 and neoplasm: It is reported that lycorine hydrochloride induces apoptosis and reduces cell proliferation by promoting the FBXW7-MCL1 axis in gastric cancer7, suppresses tumor growth of human osteosarcoma cells by blocking the Wnt/β-catenin, PI3K/AKT, and ERK1/2/MAPK signaling pathways8, and induces colorectal cancer cell apoptosis by regulating MEK2 and enhances vemurafenib activity9.