MAPK8 and colorectal cancer: For example, Triptolide inhibited head and neck cancer cell progression by inducing Gasdermin E (GSDME)-mediated cell pyroptosis 35, GSDME mediated lobaplatin-induced colorectal cancer cell pyroptosis downstream of ROS/JNK/Bax-mitochondrial apoptosis pathway and caused caspase-3/-9 activation 36.