For example, Triptolide inhibited head and neck cancer cell progression by inducing Gasdermin E (GSDME)-mediated cell pyroptosis 35, GSDME mediated lobaplatin-induced colorectal cancer cell pyroptosis downstream of ROS/JNK/Bax-mitochondrial apoptosis pathway and caused caspase-3/-9 activation 36. This evidence concerns the gene CASP3 and head and neck cancer.