In terms of clinical prognostic value, we found that GSDMC, GSDMD, GSDME and DFNB59 all displayed substantial prognostic value, but GSDMC was only associated with PFS, GSDMD was only associated with OS and DSS, and DFNB59 was only associated with OS in HCC patients, while GSDME was associated with both OS, RFS and DSS. The gene discussed is GSDMC; the disease is hepatocellular carcinoma.