The PPI networks identified 10 hub genes that were implicated in digestive tumor immunotherapy target TIM-3 (MYD88, TRAF6, IRF7, CDK4, CCND2, MAPKAP1, RICTOR, PRR5, MPP3, SERPINB6B AND PVRL3). The gene discussed is MAPKAP1; the disease is digestive system neoplasm.