TGFB1 and neoplasm: Tumor -associated macrophages (TAMs) and other M2-type macrophages can promote tumor angiogenesis, enhance cancer stemness, inhibit CTL cytotoxic T lymphocyte activity by secreting IL-10, TGF-β and other cytokines and enzymes, thus achieving immune suppression and creating an immune escape microenvironment for tumor cells 54.