BCL2 and cancer: The circumvention of apoptosis is one ofthe essential features of cancer development and progression.2 Although malignant cells are well equipped withapoptosis machinery, they tend to develop strategies to block or knockoff the programmed cell death mechanisms.3 This knock-off effect occurs when there is a defect or compromisein the apoptosis mechanism, which promotes cancer cell growth andsurvival.4 The Bcl-2 family of proteins,comprising pro- and antiapoptotic subcategories, regulates the cascadeof events that culminate in apoptosis.