Baculoviral IAP repeat-containing protein 3 (BIRC3) is a negative regulator of non-canonical nuclear factor-κB (NF-κB) signaling, and inactivation or deletion of BIRC3 in CLL results in constitutive NF-κB pathway activation, which provides pro-survival signals to the leukemic clone through upregulation of several anti-apoptotic genes[18]. Here, NFKB1 is linked to B-cell chronic lymphocytic leukemia.