CYBB and acute myeloid leukemia: The role of ROS in the context of production source was described recently by Paolillo et al., who reported a large increase in ROS in chemo-resistant AML cells and demonstrated the strong correlation with the increased level of the NOX2 subunits such as CYBA, NCF1, NCF2, NCF4, and RAC2 along with elevated expression of NOX2 (CYBB) on the cell surface of these cells[138].