CD38 and acute myeloid leukemia: CD34+ AML blasts were shown to be categorized as high and low-level ROS[106] (similar to normal marrow) with different characteristics in regard to gene expression, absolute mitochondrial content (reduced in low-ROS), ATP content (reduced in Low-ROS), cell size (reduced in Low-ROS), sensitivity to VEN (enhanced in Low-ROS), and percentage of CD38- marker (high in Low-ROS)[107].