In an AML murine model, the generated superoxide by NOX2 stimulated BM stromal cells to transfer their mitochondria to AML blast cells through AML-derived tunneling nanotubes, resulting in increased AML cells survival[140], indicating the generated ROS from non-mitochondrial source can boost OXPHOS by increasing the mitochondrial content of the AML cells. The gene discussed is CYBB; the disease is acute myeloid leukemia.