The key role of NOX2 in energy metabolism was investigated further in a recent study by Ijurko et al., where the removal of NOX2 in an in vitro AML model led to reduced glycolysis and mitochondrial respiration, while enhancing fatty acid metabolism as a source of energy production indicating the generated ROS by NOX2 has a regulatory influence on the metabolic pathway in mitochondria[117]. Here, CYBB is linked to acute myeloid leukemia.